论文部分内容阅读
冠状动脉内支架置入术的应用日趋广泛 ,但术后支架内再狭窄的发生率达 1 5 %～ 2 0 % ,研究表明 ,药物全身给药预防再狭窄的作用有限〔1〕。本文通过明胶蛋白涂层支架局部导入荧光素标记的c myc反义寡核苷酸 (ASODN) ,评估涂层支架局部给药的可行性及药物在组织中的分布。1 材
The application of coronary stenting has been widely used, but the incidence of postoperative in-stent restenosis is 15% -20%. Studies have shown that systemic administration of drugs to prevent restenosis is limited [1]. In this paper, the local injection of fluorescein-labeled c myc antisense oligonucleotide (ASODN) into gelatin-coated scaffolds was used to assess the feasibility of local administration of the scaffolds and the distribution of the drug in the tissue. 1 material