生物黏附制剂是一类药物以水凝胶聚合物为载体,通过生物黏附作用长时间黏附于黏膜而发挥疗效的药物制剂[1]。目前,人们已研制了生物黏附性散剂、片剂、凝胶、脂质体及微球等制剂,国外已有激素的口腔溃疡粘贴膜剂和片剂商品。生物黏附制剂在延长药物的作用时间,减轻药物不良反应 Bioadhesive preparation is a kind of pharmaceutical preparation which takes effect by using the hydrogel polymer as a carrier and sticking to the mucous membrane for a long time through bioadhesion [1]. At present, people have developed bioadhesive powders, tablets, gels, liposomes and microspheres and other preparations, foreign hormonal oral ulcer paste film and tablet products. Bioadhesive agents in the extension of the role of drugs to reduce adverse drug reactions