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With the high reliability and high availability they provide, active magnetic bearings (AMBs) have foundincreasing application in high-speed and high-performance turbomachinery. The oil& gas and energy industries represent core markets for AMB products and have been at the forefront of their deployment and innovation over the past three decades, driving the development of intational standards for AMB-equipped turbomachinery.Typical machinery equipped with AMBs include electric motors and generators, centrifugal compressors, turboexpanders, blowers, and pumps. Among these, high-power motor-compressors have become a major application field for AMBs in the oil&gas industry over the past two decades. Several configurations exist for motor-compressors, from standalone to hermetically sealed, and each configura-tion involves a different level of integration of the two machines. So too AMB system configurations vary, in system complexity and design challenges.This paper discusses the main motor-compressor configurations with their associat-ed challenges and benefits. The examples draw from more than 20 years of design, manufacturing and service experi-ence of high-power motor-compressors. Finally, the design framework and technical considerations driving the devel-opment of a new family of hermetically sealed motor-compressors are discussed in detail.