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The purpose of this study was to evaluate the diagnostic value of an interleukin- 6 (IL- 6) bedside test of vaginal secretions for neonatal infection in cases of preterm premature rupture of membranes. This prospective clinical study included 73 patients. Interleukin- 6 protein in vaginal secretions was determined with an immunochromatographic bedside test in < 20 minutes. Elevated C- reactive protein level (>20 mg/dL; odds ratio, 5.1; 95% CI, 0.9- 28.6) and positive interleukin- 6 level (odds ratio, 4.6; 95% CI, 1.2- 18.4) were both associated with neonatal infection. After adjustment, only interleukin- 6 remained associated with neonatal infection (odds ratio, 4.5; 95% CI, 1.1- 18.5). The sensitivity of interleukin- 6 for the prediction of neonatal infection was 79% (95% CI, 65- 92); its specificity was 56% (95% CI, 42- 70); its positive predictive value was 30% (95% CI, 12- 47), and its negative predictive value was 92% (95% CI, 84- 99). Interleukin- 6 protein determination by this new immunochromatographic test is a noninvasive prenatal vaginal marker of neonatal infection.
The purpose of this study was to evaluate the diagnostic value of an interleukin-6 (IL-6) bedside test of vaginal secretions for neonatal infection in cases of preterm premature rupture of membranes. This prospective clinical study included 73 patients. Interleukin-6 protein in vaginal secretions was determined with an immunochromatographic bedside test in <20 minutes. Elevated C-reactive protein level (> 20 mg / dL; odds ratio, 5.1; 95% CI, 0.9- 28.6) , 4.6; 95% CI, 1.2- 18.4) were both associated with neonatal infection. After adjustment, only interleukin-6 remained associated with neonatal infection (odds ratio, 4.5; 95% CI, 1.1- 18.5). The sensitivity of interleukin- Its specificity was 56% (95% CI, 42- 70); its positive predictive value was 30% (95% CI, 12-47 ), and its negative predictive value was 92% (95% CI, 84-99). Interleukin- 6 protein determination by this new immunochromatographic test is a noninvasive prenatal vaginal marker of neonatal infection.