一、引言皮肤毒理学是研究毒物经皮中毒的毒效应和作用机理的学科。随着工业的发展,同人体接触的化学物质越来越多。Schwartz1958年调查指出,因职业性皮炎所丧失的劳动时间比任何其他职业病所丧失的还多 。1973年美国政府工业卫生专家会议制订的车间空气中化学物质阈限值(TLV)表中,有些化学物质标上“皮肤”标志,表明该物质可通过皮 I. INTRODUCTION Skin toxicology is a discipline that studies the toxic effects and mechanisms of percutaneous toxicant poisoning. With the development of industry, more and more chemical substances come into contact with the human body. Schwartz’s survey in 1958 indicated that more occupational dermatitis was lost than any other occupational disease. Some chemical substances are marked with the “skin” symbol in the Workshop Air Chemical Threshold Values ​​(TLV) table developed by the 1973 U.S. Government Industrial Hygienists Conference, indicating that the substance can pass through the skin