目的　探讨线粒体肌病患者运动前后血有机酸含量的变化及其临床意义。方法　采用等速电泳法 (ITP)对 2 0例线粒体肌病患者运动前后分别抽取静脉血分离血清 ,进行检测。结果　 2 0例患者中 ,不论运动前后 ,血乳酸浓度均高于正常组 ,而磷酸浓度均低于正常组 ,两者均P <0 0 1。结论　血有机酸浓度对临床诊断线粒体肌病具有重要参考价值 ,且ITP法具有快速、简便、准确等优点 ,适用于临床常规检测 Objective To investigate the changes of blood organic acids in patients with mitochondrial myopathy before and after exercise and their clinical significance. Methods Twenty cases of mitochondrial myopathy were separated by venous blood before and after exercise with isokinetic electrophoresis (ITP). Results Among the 20 patients, the concentrations of serum lactate were higher than those of the normal group before and after exercise, while the concentration of phosphoric acid was lower than that of the normal group (P <0.01). Conclusion The blood organic acid concentration has important reference value for the clinical diagnosis of mitochondrial myopathy, and the ITP method has the advantages of fast, simple and accurate, suitable for clinical routine testing