本文报告了低毒性的紫色杆菌内毒素对小鼠造血干细胞的动员作用,并研究了动物对内毒索的敏感性与动员作用的关系。结果表明,静脉注射内毒素后,小鼠血中造血干细胞数(CFU-S)逐渐升高,第5天达高峰,为对照组的2倍。在内毒素敏感动物(ICR纯种小鼠),内毒素对粒-巨系祖细胞(CFU-GM)的动员作用明显增强。因此,预先先注射卡介苗,使机体对内毒素的敏感性提高后,内毒素可动员出更多的造血祖细胞。 This paper reports the mobilization of murine hematopoietic stem cells by low-toxic purple endotoxin and studies the relationship between animal sensitivity to endotoxic cords and mobilization. The results showed that after intravenous injection of endotoxin, the number of hematopoietic stem cells (CFU-S) in mice increased gradually and peaked on the fifth day, which was twice that of the control group. In endotoxin-sensitive animals (ICR purebred mice), mobilization of endotoxin on granulocyte-macrocyte progenitor cells (CFU-GM) was significantly enhanced. Therefore, pre-injection of BCG, the body’s sensitivity to endotoxin increased, the endotoxin can mobilize more hematopoietic progenitor cells.