论文部分内容阅读
目的分析原发性肝癌患者手术治疗后生存状况的影响因素。方法对接受手术治疗的200例原发性肝癌患者的预后进行6~82个月的随访,分析影响术后预后情况的主要因素。结果 200例原发性肝癌患者随访生存时间、中位生存时间分别为8~93个月、51.4个月。原发性肝癌患者肝硬化情况、术前甲胎蛋白水平、辅助治疗手段、术前术后甲胎蛋白变化情况及血管侵犯情况是影响原发性肝癌患者术后预后的主要危险因素(P<0.05);Logistic多因素分析表明,肝硬化程度、患者手术前后甲胎蛋白水平变化情况以及血管侵犯程度是影响原发性肝癌患者预后的独立危险因素(P<0.05)。结论影响原发性肝癌患者术后生存状况的因素众多,其中以肝硬化程度、术前及术后甲胎蛋白变化情况及血管侵犯情况为最主要因素,临床上应格外重视影响因素,及时诊断与治疗,进而提高患者术后预后情况。
Objective To analyze the influencing factors of the survival of patients with primary liver cancer after operation. Methods The prognosis of 200 patients with primary liver cancer undergoing surgical treatment was followed up for 6 to 82 months, and the main factors influencing the prognosis were analyzed. Results 200 patients with primary liver cancer were followed up for a median of survival of 8 to 93 months and 51.4 months, respectively. Primary liver cancer patients with cirrhosis, preoperative alpha-fetoprotein levels, adjuvant therapy, changes in preoperative and postoperative alpha-fetoprotein and vascular invasion is the main risk factor for postoperative prognosis of patients with primary liver cancer (P < 0.05). Logistic multivariate analysis showed that the degree of liver cirrhosis, the level of alpha-fetoprotein before and after surgery, and the extent of vascular invasion were independent risk factors for the prognosis of patients with primary liver cancer (P <0.05). Conclusion There are many factors influencing the postoperative survival of patients with primary liver cancer. Among them, the degree of cirrhosis, the changes of preoperative and postoperative alpha-fetoprotein and vascular invasion are the most important factors. In clinic, extra factors should be emphasized, and timely diagnosis should be made And treatment, and then improve the patient’s prognosis.