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目的分析美沙酮替代维持治疗合并肺结核的有效性。方法以2015年1月2日到2016年1月1日期间我院确诊收治的66例肺结核患者作为研究对象,将其分为两组,每组33例。观察组为初治的吸毒肺结核患者,对照组为初治的非吸毒肺结核患者,给予美沙酮替代治疗,对比两组的治疗依从率以及治疗效果。结果观察组治疗总依从率、治愈率、不良反应发生率为:51.5%、66.7%、48.5%、对照组分别为81.8%、97%、18.2%,对比有统计学意义(P<0.05)。结论美沙酮代替维持治疗合并肺结核对于有吸毒史的患者有着比较明显的疗效,在治疗期间需要根据患者的具体情况调整用量,以降低不良反应的发生。
Objective To analyze the effectiveness of methadone replacement maintenance therapy in combination with pulmonary tuberculosis. Methods Sixty-six cases of pulmonary tuberculosis diagnosed in our hospital from January 2, 2015 to January 1, 2016 were divided into two groups (33 in each group). The observation group was newly diagnosed drug-induced pulmonary tuberculosis patients. The control group was untreated non-drug-eluting pulmonary tuberculosis patients. Methadone replacement therapy was used to compare the two groups’ treatment compliance rate and therapeutic effect. Results The total follow-up rate, cure rate and adverse reaction rate in the observation group were 51.5%, 66.7% and 48.5%, respectively, which were 81.8%, 97% and 18.2% respectively in the control group (P <0.05). Conclusion Methadone replacement therapy and pulmonary tuberculosis in the treatment of patients with a history of drug abuse have a more obvious effect, during treatment need to be adjusted according to the specific circumstances of patients to reduce the incidence of adverse reactions.