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米索前列醇是具有使子宫收缩的一种前列腺素类似物,为确定阴道给药能否有效引起早孕流产,作者对58位健康自愿受试者进行了前瞻性临床试验。 入选对象为孕龄≤10周,年龄18～45岁,自愿终止妊娠的妇女。有明显子宫感染,用药前子宫出血,任何程度的宫颈扩张,贫血(血球压积<30％),心血管或脑血管疾患,对前列腺素过敏或有禁忌均不纳入研究。对象被随机分成了3组,A组为单独经阴道给与米索前列醇;B组为首剂给米索前列醇立即口服他莫西芬20mg;C组为用米索前列醇前
Misoprostol is a prostaglandin analogue that has been shown to constrict the uterus. To determine if vaginal administration can effectively cause early pregnancy miscarriage, the prospective trial of 58 healthy volunteers was conducted. Participants were pregnant women ≤ 10 weeks, aged 18 to 45 years, voluntary termination of pregnancy in women. There are obvious uterine infections, uterine bleeding before treatment, any degree of cervical dilation, anemia (hematocrit <30%), cardiovascular or cerebrovascular disease, allergy to prostaglandins, or contraindications to failure. Subjects were randomly divided into 3 groups, Group A was given vaginal misoprostol alone; Group B was given the first dose of misoprostol for oral administration of tamoxifen 20mg; Group C was treated with misoprostol