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目的探讨玉屏风散发酵液对免疫抑制小鼠免疫功能的调节作用。方法用环磷酰胺制备免疫抑制小鼠模型,分别用玉屏风散煎剂和玉屏风散发酵液灌胃,剂量为9.375g/kg,连续给药10天。空白对照组和模型组用蒸馏水灌胃。测定小鼠脾指数、胸腺指数、脾抗体细胞形成数。结果同玉屏风散煎剂相比,玉屏风散发酵液能明显改善由环磷酰胺所导致的小鼠脾和胸腺萎缩,以及脾抗体细胞形成数的减少。结论玉屏风散发酵液能明显改善免疫抑制小鼠的免疫功能低下状态。
Objective To investigate the regulatory effect of Yupingfeng Powder on immune function in immunosuppressed mice. Methods The immunosuppressive mouse model was prepared with cyclophosphamide. The mice were intragastrically administered with Yupingfeng Powder and Yupingfeng Powder, and the dose was 9.375g/kg for 10 consecutive days. The blank control group and model group were treated with distilled water. The mouse spleen index, thymus index, and number of spleen antibody cells were measured. Results Compared with Yupingfengsan decoction, Yupingfeng Powder could significantly improve the atrophy of spleen and thymus caused by cyclophosphamide and decrease the number of splenic antibody cells. Conclusion Yupingfeng Powder can significantly improve the immune function of immunosuppressed mice.