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目的了解抗结核板式组合药治疗初治涂阳肺结核不良反应发生情况。方法 246例初治涂阳病例随机分为2组,甲组110例,服用2HRZE/4H3R3板式组合药,乙组136例,服用2H3R3Z3E3/4H3R3板式组合药。治疗中每月门诊随访检查血常规、肝肾功能。结果甲组消化道反应发生率10.9%,肝功能损害7.3%,过敏性皮炎5.5%,关节疼痛0.9%,白细胞减少2.7%;乙组分别为11.8%,8.1%,5.9%,1.5%,3.7%。两组差异无统计学意义(P>0.05)。结论 2HRZE/4H3R3化疗方案与2H3R3Z3E3/4H3R3化疗方案对治疗初治涂阳病人均是安全有效的,2种板式组合药不良反应以胃肠道反应最多见,大多数不良反应症状较轻,临床使用安全。
Objective To understand the anti-TB plate combination therapy of initial smear-positive pulmonary tuberculosis adverse reactions. Methods A total of 246 newly diagnosed smear positive cases were randomly divided into two groups. 110 cases in group A received 2HRZE / 4H3R3 plate combination and 136 cases in group B received 2H3R3Z3E3 / 4H3R3 plate combination. Follow-up visits during the treatment of blood routine examination, liver and kidney function. Results Group A gastrointestinal reaction rate of 10.9%, liver dysfunction 7.3%, allergic dermatitis 5.5%, joint pain 0.9%, leukopenia 2.7%; B were 11.8%, 8.1%, 5.9%, 1.5%, 3.7 %. There was no significant difference between the two groups (P> 0.05). Conclusions The 2HRZE / 4H3R3 chemotherapy regimen and the 2H3R3Z3E3 / 4H3R3 chemotherapy regimen are both safe and effective for the treatment of newly diagnosed smear positive patients. The adverse reactions of the two kinds of plate combination are most common in the gastrointestinal tract and most of the adverse reactions are mild. The clinical use Safety.