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目的:通过对锰接触者体内神经传导介质的测定,了解其变化规律,为锰中毒的早期诊断提供科学依据。方法:对63名锰接触者的血中多巴胺(DA)、去甲肾上腺素(NE)、尿中5-羟吲哚醋酸(5-HIAA)进行测定。结果:DA、NE、5-HIAA含量锰接触组为(20371±3928)ngdl、(6536±649)ngdl、(589±474)mg24h,对照组为(35176±4119)ngdl、(12676±1090)ngdl、(1491±723)mg24h,经统计学处理差异有显著性。结论:锰接触者体内DA、NE、5-HIAA减少。
OBJECTIVE: To determine the change of nerve conduction mediators in manganese exposure and to provide a scientific basis for the early diagnosis of manganese poisoning. Methods: The blood levels of dopamine (DA), norepinephrine (NE) and urinary 5-HIAA in 63 manganese exposed persons were measured. RESULTS: The levels of DA, NE and 5-HIAA in the manganese exposure group were (20371 ± 3928) ngdl, (6536 ± 649) ngdl, and 589 ± 474 mg24h, respectively, and those in the control group were 35176 ± 4119 ngdl and 12676 ± 1090, ngdl, (1491 ± 723) mg24h, the difference was statistically significant. Conclusions: The levels of DA, NE and 5-HIAA in manganese contact persons decreased.