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目的探讨深度水解蛋白配方奶粉在新生儿坏死性小肠结肠炎(NEC)治疗中的作用,以探寻新的治疗新生NEC的方法。方法将2012年1月至2014年2月诊治的NEC患儿85例随机分为治疗组42例和对照组43例,在患儿家属均知情同意的前提下,治疗组开奶初期应用深度水解蛋白配方奶粉;对照组开奶初期应用早产儿配方奶粉。通过观察两组患儿开奶后喂养耐受情况、住院天数、出院体重评价宫外生长发育迟缓(EUGR)发生率、再次开奶达到全肠内喂养时间等来了解深度水解蛋白配方奶粉在新生儿NEC治疗中的作用。结果治疗组患儿达到全肠内喂养时间[(10.1±1.2)d]和住院时间[(41±3.2)d]均短于对照组[(17.3±1.9)d和(49±5.3)d,P均<0.05],喂养不耐受次数少于对照组[(1.3±0.2)次vs(2.1±0.3)次,P<0.05];治疗组患儿出院体重评价EUGR率,与对照组比较差异无统计学意义(47.6%vs 67.4%,P>0.05)。结论深度水解蛋白配方奶粉可应用在新生儿NEC的恢复期开奶中,效果优于早产儿配方奶粉。
Objective To investigate the role of deep-hydrolyzed protein formula in the treatment of neonatal necrotizing enterocolitis (NEC), in order to explore a new method for the treatment of neonatal NEC. Methods 85 patients with NEC diagnosed and treated from January 2012 to February 2014 were randomly divided into treatment group (n = 42) and control group (n = 43). Under the informed consent of family members, the treatment group was treated with deep hydrolysis Protein formula milk powder; control group early milk formula milk powder premature children. By observing the two groups of children after feeding milk tolerance, length of hospital stay, discharge weight evaluation of ectopic pregnancy growth retardation (EUGR) incidence, reopened to achieve total enteral feeding time to understand the deep hydrolysis protein formula in freshmen The role of children in NEC treatment. Results The total enteral feeding time [(10.1 ± 1.2) d] and hospital stay [(41 ± 3.2) d] in the treatment group were shorter than those in the control group [(17.3 ± 1.9) days and (49 ± 5.3 days) P <0.05], and the frequency of feeding intolerance was less than that of the control group [(1.3 ± 0.2) vs (2.1 ± 0.3) times, P <0.05]. The EUGR rate of discharged children in the treatment group was significantly lower than that in the control group No statistical significance (47.6% vs 67.4%, P> 0.05). Conclusion Deep-hydrolyzed protein formula milk can be used in the recovery of neonatal NEC in milk, the effect is better than that of preterm infant formula.