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本研究系口服青蒿琥酯预防血吸虫病的现场研究,于1997年7月～9月在望江的杨河试区及贵池的沙山试区分别选择易感人群624、286例,将受试对象随机分成两组,按双盲法分服青蒿琥酯和安慰剂,剂量均为6mg/kg 顿服,受试对象在接触疫水后2周开始服药,每2周1次,连服4次,停止服药后4周用尼龙绢集卵孵化+Kato-Katz 法进行效果评价。结果表明,杨河试区服青篙琥酯片者孵化阳性2例,阳性率为0.73%;对照组粪检阳性11例,阳性率为3.83%,感染度几何均数为26.40±1.49。沙山试区服青蒿琥酯者无1例粪检阳性病例,而服安慰剂的对照组,粪检阳性7例,感染率为6.54%,感染度几何均数为14.23±2.14。两试区对血吸虫病的预防保护率分别为80.94%、100%。在试验过程中两组观察对象均有部分出现腹痛、恶心等胃肠道刺激及头昏、乏力等症状,但反应均较轻微。且两组副反应率差异无显著性,服药前后两组受试对象肝、肾功能,网织红细胞和心电图检查未见明显变化。
This study was the field study of oral artesunate in the prevention of schistosomiasis. From July to September 1997, 624,286 cases of susceptible population were selected in Yang River Trial Area of Wangjiang and Shashan Area of Guichi, The subjects were randomly divided into two groups, according to double-blind treatment of artesunate and placebo, the dose was 6mg / kg Dayton, the subjects in contact with water 2 weeks after the start of medication, once every 2 weeks, Serve 4 times, stop taking 4 weeks after taking nylon silk hatching eggs + Kato-Katz method for evaluation. The results showed that Yanghe testosterone tablet hatching positive in 2 cases, the positive rate was 0.73%; the control group of fecal positive in 11 cases, the positive rate was 3.83%, the average geometric mean infection was 26.40 ± 1.49. There was no case of positive stool test in artesunate of Shashan experimental group. In the control group taking placebo, there were 7 cases of positive stool test, the infection rate was 6.54%, and the geometric mean of infection was 14.23 ± 2.14. Prevention and protection rates of schistosomiasis in two experimental areas were 80.94% and 100% respectively. In the course of the experiment, some subjects in the two groups experienced symptoms such as abdominal pain, nausea and gastrointestinal motility, dizziness and fatigue, but the responses were mild. There were no significant differences in the incidence of side effects between the two groups. There was no significant change in the liver, kidney function, reticulocyte and electrocardiogram in the two groups before and after taking the drug.