【摘 要】
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Biomaterial based scaffolds for treating large bone defects require excellent biocompatibility and osteoconductivtty.Here we report on the fabrication of hydrox
【机 构】
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Australian Institute for Bioengineering and Nanotechnology,The University of Queensland,St.Lucia,QLD
论文部分内容阅读
Biomaterial based scaffolds for treating large bone defects require excellent biocompatibility and osteoconductivtty.Here we report on the fabrication of hydroxyapatite-dendritic mesoporous silica nanoparticles (HA-DMSN) based scaffolds with hierarchical micro-pores (5 pm) and nano-pores (6.4 nm),and their application for bone regeneration.The in vitro studies demonstrated good biocompatibility of dissolution extracts,as well as enhanced osteogenic potential indicated by does-dependent upregulation of bone marker gene expression (osteocalcin gene (OCN),osteopontin gene (OPN),collagen type Ⅰ alpha 1 gene (CoL1A1),runt-related transcription factor 2 gene (RUNX2),and integrin-binding sialoprotein gene (IBSP)),alkaline phosphatise (ALP) activity,and alizarin red staining.The in vivo studies showed that HA-DMSN scaffolds significantly increased bone formation in a rat cranial bone defect model after 4 weeks healing.Our study provides a simple method to fabricate promising inorganic scaffolds with hierarhical pores for bone tissue engineering.
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