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目的 预防肾移植术后心血管并发症 ,提高肾移植病人长期存活率。 方法 采用非侵入性方法对 86例肾移植术后病人昼夜血压变化和 2 4h动态心电图进行连续监测 ,并对数据进行比较分析。 结果 86例病人发生高血压者 5 5例 ,病人昼夜平均血压差别、昼夜心电图ST段或T波的异常改变平均次数差别有显著性意义。昼夜CsA浓度差别、昼夜血肌酐、血清胆固醇、血糖、甘油三脂及K+ 、Na+ 、Cl-、TCO2 、Ca2 + 等指标差别无显著性意义。 结论 肾移植术后心血管并发症可能与夜间高血压发生率高有关 ,昼夜血压节律消失与抗排斥反应药物及常规抗高血压药物无关。
Objective To prevent cardiovascular complications after renal transplantation and improve the long-term survival rate of renal transplant patients. Methods Noninvasive methods were used to monitor the changes of diurnal blood pressure and 24 hours Holter monitoring of 86 patients after renal transplantation. The data were compared and analyzed. Results In 86 patients with hypertension, 55 patients had significant difference in the average difference in day and night blood pressure, the mean number of abnormal changes of ST segment or T wave in day and night electrocardiogram. The difference of day and night CsA concentration, diurnal serum creatinine, serum cholesterol, blood glucose, triglycerides and K +, Na +, Cl-, TCO2, Ca2 + and other indicators no significant difference. Conclusions Cardiovascular complications after renal transplantation may be related to the high incidence of nocturnal hypertension. The disappearance of circadian blood pressure rhythm has nothing to do with anti-rejection drugs and conventional antihypertensive drugs.