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细胞生长和分化等生命基本活动所必需的蛋白质酪氨酸磷酸化过程是由蛋白质酪氨酸激酶(protein tyrosine kinases PTKs)和蛋白质酪氨酸磷酸酶(protein tyrosine phosphatases,PTPs)之间的协调作用所决定。细胞信息传递过程中,根据细胞的反应不同,PTKs和PTPs相互间发生拮抗和协同作用,而两者之间的平衡失调,可影响正常细胞的生长并与细胞发生恶性转化有关。自1980年Hunter研究Rous肉瘤病毒致痛机理时发现癌基因Src的表达产物具有PTKs活性以来,认识到蛋白质酪氨酸磷酸化过程对细胞的增殖、分化和癌变有直接的关系。肝细胞各种促分裂因子的受体大部分是通过酪氨酸激酶传递信息,就此对酪氨酸介导的细胞内信息传递与肝细胞的增殖、癌变的关系作一概述。
Protein tyrosine phosphorylation, which is essential for essential activities such as cell growth and differentiation, is coordinated by protein tyrosine kinases (PTKs) and protein tyrosine phosphatases (PTPs). Decided. In the process of cell information transmission, depending on the cellular response, PTKs and PTPs are antagonistic and synergistic, and the imbalance between the two may affect the growth of normal cells and are associated with the malignant transformation of cells. Since Hunter studied the Rous sarcoma virus causing mechanism in 1980, it was discovered that the expression product of the oncogene Src has PTKs activity, and it has been recognized that the protein tyrosine phosphorylation process has a direct relationship with cell proliferation, differentiation, and canceration. Most of the receptors for various mitogens of hepatocytes are transmitted through tyrosine kinases, and an overview of the relationship between tyrosine-mediated intracellular message transmission and the proliferation and carcinogenesis of hepatocytes is provided.