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本文报道了应用吡喹酮40mg/kg或50mg/kg一次口服治疗200例曼氏血吸虫病的疗效。患者的年龄为6～63岁,15岁以下33例(16.5%)。药物的主要副作用有头晕(27.5%)、嗜眠(21.0%)、腹部绞痛(17.5%)恶心(16.0%)、腹泻(9.0%)、头痛(7.5%)、呕吐(4.0%)、发热(2.0%)、痢疾(1.0%)、寒战(1.0%)、皮疹(1.0%)及荨麻疹(0.5%)等。在治疗前后作血细胞计数、肝功能和肾功能试验,并作心电图及脑电图检查以评价药物的毒性。结果上述各项指标在服药后均无明显变化,在治疗后6个月的随访期间对
This article reports the efficacy of oral administration of praziquantel 40 mg / kg or 50 mg / kg in 200 cases of Schistosoma mansoni. The patients were 6 to 63 years old and 33 under 15 years old (16.5%). The main adverse drug effects were dizziness (27.5%), narcolepsy (21.0%), abdominal cramps (17.5%), nausea (16.0%), diarrhea (9.0%), headache (7.5%), vomiting 2.0%), dysentery (1.0%), chills (1.0%), rashes (1.0%) and urticaria (0.5%). Before and after treatment for blood cell count, liver function and renal function tests, and for ECG and EEG examination to evaluate the toxicity of drugs. Results The above indicators did not change significantly after taking the drug, and after 6 months of follow-up