蛋白激酶C θ(PKCθ)是PKC家族新型PKC组成员之一,主要选择性地表达于T淋巴细胞和骨骼肌细胞。它对于T细胞发育无明显作用, 但在TCR/CD28双信号触发成熟T细胞的活化与增殖中具有重要意义, 是介导TCR激活T细胞的关键亚型之一。近年来的研究表明, PKCθ在T细胞活化、失能、生 Protein kinase C θ (PKCθ) is a member of the PKC family of novel PKC families and is predominantly expressed on T lymphocytes and skeletal muscle cells. It has no significant effect on the development of T cells, but it is important in triggering the activation and proliferation of mature T cells by TCR / CD28 dual signal and is one of the key subtypes that mediate TCR-activated T cells. In recent years, studies have shown that, PKCθ in T cell activation, disability, health