论文部分内容阅读
目的研究米诺环素对实验性大鼠蛛网膜下腔出血(SAH)所致神经炎症及脑血管病变的影响。方法单线穿刺法制备大鼠SAH模型;用神经功能评分检测各组大鼠的神经损害程度;ELISA检测大鼠皮层细胞因子肿瘤坏死因子α(TNF-α)和白细胞介素1β(IL-1β)的水平;Western blot法检测脑组织小胶质细胞/巨噬细胞标志物离子钙结合接头蛋白分子1(Iba-1)的水平;HE染色检测脑血管壁的形态学变化。结果成功制备实验性SAH大鼠模型;米诺环素治疗后SAH大鼠神经功能得到明显改善、脑组织中TNF-α和IL-1β水平下降、小胶质细胞/巨噬细胞活化受到抑制、血管痉挛和血管壁损伤得到明显缓解。结论米诺环素抑制SAH大鼠脑组织小胶质细胞/巨噬细胞活化改善血管病变。
Objective To study the effect of minocycline on neuroinflammation and cerebrovascular diseases induced by subarachnoid hemorrhage (SAH) in experimental rats. Methods SAH model was established by single-wire puncture. The degree of nerve damage in each group was detected by neurological function score. The levels of tumor necrosis factor-α (TNF-α) and interleukin-1β (IL- The level of Iba-1 in microglia / macrophage marker was determined by Western blot. The morphological changes of cerebrovascular wall were detected by HE staining. Results The experimental SAH rat model was successfully established. The neurological function of SAH rats was significantly improved after treatment with minocycline, the levels of TNF-α and IL-1β in brain tissue were decreased, the activation of microglia / macrophage was inhibited, Vasospasm and vascular wall damage were significantly alleviated. Conclusion Minocycline can inhibit the activation of microglia / macrophage in the brain of SAH rats and improve the vascular lesions.