卵巢癌是妇科常见的恶性肿瘤,因其位居盆腔,早期多无明显症状,75%～85%患者确诊时已属晚期,5年生存率小于15%,而Ⅰ期患者5年生存率可达90%,故早期诊断是关键,但目前临床上缺乏有效可靠的诊断方法。20世纪60年代,Voget首次报道溶血磷脂酸(LPA)具有多种生理效应,在体内信号传递中 Ovarian cancer is a common gynecological malignant tumor, because of its location in the pelvis, no obvious symptoms early, 75% to 85% of patients diagnosed late, 5-year survival rate of less than 15%, while the 5-year survival rate of patients with stage Ⅰ Up to 90%, so early diagnosis is the key, but the clinical lack of effective and reliable diagnosis. In the 1960s, Voget reported for the first time that lysophosphatidic acid (LPA) has a variety of physiological effects in vivo signaling