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目的 观察四君子汤对免疫抑制小鼠免疫功能及肝脏细菌易位的影响,探讨神经-内分泌-代谢-微生态-免疫网络之间的关系。方法 应用氢化可的松制备小鼠免疫功能抑制模型,造成肝脏细菌易位;观察四君子汤对小鼠吞噬细胞功能的影响和细菌易位的控制,同时设自然恢复组和正常对照组进行比较。结果 氢化可的松灌喂3d后,小鼠吞噬细胞的吞噬功能明显下降,肝脏出现大量细菌易位;经四君子汤治疗6 h后,小鼠吞噬细胞吞噬功能显著提高,肝脏细菌易位明显减少。结论 四君子汤能有效地控制免疫抑制小鼠肝脏细菌易位
Objective To observe the effect of Sijunzi decoction on immune function and liver bacterial translocation in immunosuppressive mice, and explore the relationship between neuroendocrine-metabolism-microecological-immune network. Methods Hydrocortisone was used to prepare the model of immune function inhibition in mice, which caused the translocation of bacteria in the liver. The effect of Sijunzi decoction on the phagocyte function of mice and the control of bacterial translocation were observed. The natural recovery group was compared with the normal control group. Results After fed with hydrocortisone for 3 days, the phagocytic function of phagocytic cells of mice was significantly decreased, and a large number of bacterial translocations occurred in the liver. After treatment with Sijunzi Decoction for 6 h, the phagocytic function of phagocytic cells of mice was significantly increased, and the bacterial translocation of liver was significantly reduced. . Conclusion Sijunzi Decoction can effectively control the liver bacterial translocation in immunosuppressive mice