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目的：探讨大鼠重度脑外伤后胃粘膜血流（ＧＭＢＦ）、胃泌酸动态变化及与急性胃粘膜损伤的相关性。方法：将４９只雄性ＳＤ大鼠随机分为７组，即对照组、液压打击重度颅脑伤后３０ｍｉｎ，１，２，４，８及１６ｈ组。观察各组动物的ＧＭＢＦ、胃液ｐＨ值及粘膜损伤面积。结果：与对照组相比，伤后３０ｍｉｎＧＭＢＦ明显升高（Ｐ＜０．０１），１ｈ后明显持续降低（Ｐ＜０．０１）；伤后３０ｍｉｎ后胃液ｐＨ持续降低（Ｐ＜０．０１），直至伤后１６ｈ开始明显高于对照组（Ｐ＜０．０１）；致伤３０ｍｉｎ后随时间延长，胃粘膜损伤面积逐渐增加，与ＧＭＢＦ及ｐＨ值呈明显负相关。结论：大鼠重度脑外伤所致胃粘膜血流降低、胃酸分泌亢进与胃粘膜损伤程度有明显相关性。
Objective: To investigate the dynamic changes of gastric mucosal blood flow (GMBF), gastric acid secretion and acute gastric mucosal injury after severe traumatic brain injury in rats. Methods: Forty nine male Sprague-Dawley rats were randomly divided into 7 groups: control group, hydraulic impaction 30 min, 1, 2, 4, 8 and 16 h after TBI. The GMBF, gastric pH and mucosal lesion area of each group were observed. Results: Compared with the control group, the GMBF at 30 min after injury significantly increased (P <0.01) and decreased significantly after 1 h (P <0.01). After 30 min, the gastric pH decreased continuously (P <0.01) , Which was significantly higher than that of the control group at 16h after injury (P <0.01). After 30min of injury, the area of gastric mucosal lesion gradually increased with the increase of time, which was negatively correlated with GMBF and pH. CONCLUSION: Gastric mucosal blood flow decreased and gastric hypersecretion was significantly associated with the degree of gastric mucosal injury in rats with severe traumatic brain injury.