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目的观察在大量输血的情况下,输入完全不相同比例的红细胞以及血浆对由于创伤性而出现失血患者的救治影响。方法回顾性分析创伤性失血患者128例作为此次研究对象,同时所选取的患者全部需要输入>10 U悬浮红细胞。按照相关标准,入院24小时内所输入的血浆和悬浮红细胞的比例,将所选取的患者分成低比例组、高比例组以及中比例组。对比患者通过大量输血之前与大量输血之后与3组的凝血功能指标、入院接受治疗时间段内红细胞输入的总量以及生产差异。结果和输血之前实施对比可以发现,中比例组与高比例组患者通过一定量的输血之后PT-INR以及APTT没有非常明显的改变,而低比例组的PT-INR以及APTT升高非常明显(P<0.01)。高比例组、中比例组以及低比例组患者通过输血之后其凝血功能的相关标准、在院接受治疗的时间段内红细胞的输入总量差异有统计学意义(P<0.05)。另外在院接受治疗的时间段内红细胞所输入的总量3组患者也各不相同,不过生存差异无统计学意义。结论在大量输血的情况下,低、中和高比例的输注血浆实施对比可以发现,高比例的输注对预防创伤性失血患者出现凝血功能障碍非常有利,可以显著减轻患者住院时间段内红细胞的输入总量,最终能够有效节约血液资源。
Objective To observe the effects of transfusion of red blood cells with completely different proportions and the effect of plasma on the patients with traumatic bleeding. Methods A retrospective analysis of 128 patients with traumatic hemorrhage as the object of this study, while the selected patients all need to enter> 10 U suspended red blood cells. According to the relevant standards, the proportion of plasma and suspended erythrocytes input within 24 hours after admission were divided into low proportion group, high proportion group and medium proportion group. The patients were compared before and after massive blood transfusion with coagulation function indicators of three groups after admission, the total amount of input of red blood cells within the treatment period and the production difference. Results Compared with those before transfusion, PT-INR and APTT were not significantly changed after a certain amount of blood transfusion in patients of medium and high proportions, while PT-INR and APTT of patients in low proportions were significantly increased (P <0.01). The total amount of erythrocytes in the high-dose group, medium-weight group, and low-proportion group after passing blood transfusion was related to the coagulation function, and the difference was statistically significant (P <0.05). In addition, during the period of hospital treatment, the total amount of red blood cells input into the three groups varies, but the difference in survival is not statistically significant. Conclusions In the case of massive blood transfusion, the comparison of low, medium and high proportion of infusion plasma shows that high infusion rate is very beneficial in preventing coagulation dysfunction in patients with traumatic blood loss and can significantly reduce the number of red blood cells The total amount of input, and ultimately can effectively save blood resources.