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在偏头痛和其它血管性头痛中，一氧化氮（NO）可能起着重要的作用，因为作为NO供体的硝酸甘油和可促进内皮NO生成的组胶均可以引起具有搏动性、剂量依赖性等几种偏头痛特点的头痛。较高剂量的硝酸甘油可诱发偏头痛患者的头痛发作，并加重其症状和延长脑动脉扩张时间。本文研究提示，偏头痛可能是由于NO触发的反应系统中某种酶的数量增加和／或亲和力的提高引起的；其它血管性头痛的发作可能也与NO有关。
Nitric oxide (NO) may play an important role in migraine and other vascular headaches because nitroglycerin, an NO donor, and colloids that promote NO production in the endothelium can cause a pulsatile, dose-dependent Several migraine headache and other characteristics. Higher doses of nitroglycerin can induce headache in migraine sufferers and exacerbate their symptoms and prolong cerebral arterial dilatation. Our study suggests that migraine may be due to an increased number of enzymes and / or increased affinity for certain enzymes in NO-triggered response systems; the onset of other vascular headaches may also be related to NO.