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实验性变态反应性脑脊髓炎(简称EAE)是一种人工诱导的中枢神经系统自身免疫性疾病,也是自身免疫病的代表模式。关于EAE的免疫损伤机理,大多数学者认为致敏T细胞是引起EAE免疫损伤的主要原因;但也有报告指出:抗体也参与其损伤过程。有关这个问题的意见尚不统一。我们曾经在建立模型、提取髓磷脂硷蛋白(简称Bp)以及特异性免疫应答等方面做过一些工作。本文则以不同的实验手段和方法对EAE致病的主要原因作一系统观察,并对其可能的机理作出粗浅的分析。材料与方法一、动物及分组:豚鼠,由本校动物室供应。实验设有不同月龄组(4月龄,2 1/2月龄,1 1/2月龄)和新生期胸腺切除组,共4个组别,后者为2 1/2月龄,体重450g左右。各相应组别中,雌雄成比例分配。
Experimental allergic encephalomyelitis (EAE) is an artificially induced central nervous system autoimmune disease and is also a representative model of autoimmune diseases. On the mechanism of immune damage in EAE, most scholars believe that sensitized T cells are the main cause of immune damage caused by EAE; however, it is also reported that antibodies also participate in the process of their injury. Opinions on this issue are not uniform. We have done some work in establishing models, extracting myelin basic protein (Bp), and specific immune response. In this paper, different experimental methods and methods of EAE pathogenesis of a systematic observation of the main reasons for its possible mechanism to make a superficial analysis. Materials and methods First, animals and groups: guinea pigs, animal supply room by the school. There were 4 groups (4 months, 21 1/2 months, 11/2 months old) and neonatal thymectomy group, which were divided into 4 groups. The latter group was 21 1/2 months old and the body weight About 450g. The corresponding groups, male and female in proportion to the distribution.