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复发性流产病因复杂,母胎免疫成为该领域的研究热点。母胎免疫特点是以辅助性T细胞(Th2)和调节性T细胞(Treg)为优势的免疫平衡,Th17是与白细胞介素(IL)23相关的、能够分泌IL-17的T细胞亚群。近期研究发现,母胎界面IL-23升高,Treg/Th17失衡导致Th17偏移,IL-17升高引起的细胞因子微环境的改变与不明原因复发性流产有关。该文就IL-23和IL-17在不明原因复发性流产发病机制中的作用予以综述。“,”The pathogenesis of Recurrent spontaneous abortion is complicated. The maternal-fetal immu-nity has become a research hotspot in this field. Maternal-fetal immune is an immune balance with T helper cell ( Th) 2 and regulatory T cell ( Treg) dominance. Th17 cell is a T-cell subset which can secret IL-17 and have close relationship with IL-23. Recent studies have revealed that the balance disorder between Th17 cells and immunosuppressive regulatory T cell( Treg) plays a key role in the pathological pregnancy by breaking the maternal-fetal immunetolerance,accompanied by the elevated level of IL-23 and IL-17. Here is to make a review of the role of IL-23 and IL-17 in the pathogenesis of unexplained recurrent miscarriage.