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近年来广泛应用放射免疫双抗测定血浆中的βhCG(简称βhCG-RIA),用以滋养细胞肿瘤的诊断、疗效观察、以及治疗后的随访,其准确性较高。但是,应用随意尿代替血测定βhCG报道甚少,为此,我们对随意尿βhCG放射免疫测定在滋养细胞肿瘤诊断和疗效监测上的价值进行了探讨,现将结果报道如下: 随意尿标本取自1984年3月～1985年2月在我院妇产科住院的滋养细胞肿瘤病人,共20例。病人按首都医院诊断及分期标准,良性葡萄胎6例,恶性葡萄胎13例,其中Ⅰ期8例,Ⅲ_A5例,绒癌1例(Ⅰ期)。治疗:6例良性葡萄胎均各刮宫2次,待无阴道流血后出院,门诊随访观察;14例恶性葡萄胎及绒癌,用5-Fu及KSM联合化疗,至血βhCG<3ng/ml后,巩固2个疗程出院。
In recent years, extensive use of radioimmunoassay in the determination of plasma βhCG (referred to as βhCG-RIA), for the diagnosis of trophoblastic tumors, the efficacy of observation, and follow-up after treatment, its accuracy is high. However, the application of random urine instead of blood determination of βhCG rarely reported, therefore, we random urine βhCG radioimmunoassay in the diagnosis of trophoblastic tumors and the efficacy of the monitoring were discussed, the results reported as follows: Random urine samples taken from 1984 March ~ 1985 February in our hospital obstetrics and gynecology hospitalized trophoblastic tumor patients, a total of 20 cases. Patients according to the Capital Hospital diagnosis and staging criteria, 6 cases of benign hydatidiform mole, 13 cases of malignant mole, of which 8 cases of Ⅰ, Ⅲ_A5 cases, 1 cases of choriocarcinoma (Ⅰ). Treatment: 6 cases of benign mole were curettage two times, to be discharged after no vaginal bleeding, outpatient follow-up observation; 14 cases of malignant mole and choriocarcinoma with 5-Fu and KSM combined chemotherapy to serum βhCG <3ng / ml , Consolidate two courses of discharge.