人精子特异性乳酸脱氢酶(hLDH-C4)具有组织器官特异性及较强的免疫原性。多项研究表明其诱导的免疫反应在多种哺乳动物具有抗生育性:在血清中都检测到抗LDH-C4的抗体,动物的生育率明显降低,且作用可逆。LDH-C4作为疫苗用于免疫生育调节一直受到关注。作者构建了精子特异性乳酸脱氢酶真核表达载体 Human sperm-specific lactate dehydrogenase (hLDH-C4) has tissue-organ specificity and strong immunogenicity. A number of studies have shown that the induced immune response has antifertility in a variety of mammalian species: Anti-LDH-C4 antibodies are detected in serum and the animals have significantly reduced fertility and reversible effects. The use of LDH-C4 as a vaccine for immunomodulation regulation has drawn attention. The authors constructed a sperm-specific lactate dehydrogenase eukaryotic expression vector