论文部分内容阅读
皮肤是机体和外界环境接触的主要屏障，机体皮肤屏障功能下降可产生多种炎症性皮肤病。体表脂膜是皮肤屏障的重要组成部分，包括表皮细胞和皮脂腺来源的脂类。近来多项研究表明，皮脂腺的改变及其分泌的脂类与多种炎症性皮肤病的发展进程紧密相关，其中包括寻常痤疮，特应性皮炎，银屑病，酒渣鼻和脂溢性皮炎，对皮脂腺的功能研究将为相关炎症性皮肤病提供新的治疗思路，但目前仍需进一步的研究证实皮脂腺的重要作用，从而提供更充分的临床依据。“,”Skin is an important interface between the host and its environment. Disrupted skin barrier function may lead to many inlfammatory dermatoses.The skin surface lipid iflm, an important component of the skin barrier, comprises a mixture of keratinocyte and sebaceous gland-derived lipids.Recent evidence demonstrated that defective sebaceous gland-derived lipids synthesis predisposes for the development of skin inlfammatory diseases, including acne vulgaris, atopic dermatitis,psoriasis, rosacea, and seborrheic dermatitis.The studies on the function of the sebaceous glands may provide new thoughts of therapy for relative inflammatory dermatoses. But now we need more researches to conform the importance of the contribution of sebaceous glands to barrier function, then provide more adequate clinical basis.