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目的:研究结肠炎定位片在家犬体内的药物动力学。方法:8条健康家犬,采用双交叉实验设计随机分为2组,分别给予结肠炎片和结肠炎定位片,用HPLC法测定家犬血浆及肠道内容物中大黄素含量,PKS程序拟合模型并计算药动学参数。结果:结肠炎片和结肠炎定位片的t_(max)分别为(2.43±1.20)h和(6.26±1.18)h,C_(max)分别为(40.05±7.63)mg·L~(-1)和(29.23±5.91)mg·L~(-1),AUC_(0-t)分别为(408.22±81.27)mg·h·L~(-1)和(413.21±89.04)mg·h·L~(-1)。家犬在口服结肠炎定位片约6.5h后结肠中大黄素的量较多,而小肠中几乎未检测到大黄素。结论:结肠炎定位片在家犬体内达到了理想的口服结肠定位给药目的。
Objective: To study the pharmacokinetics of colitis locating tablets in dogs. Methods: Eight healthy dogs were randomly divided into two groups according to the double-crossover design. Colitis tablets and colitis plaques were given respectively. The contents of emodin in plasma and intestinal contents of dogs were determined by HPLC method. PKS program Model and calculate pharmacokinetic parameters. RESULTS: The t max of colitis tablets and colitis plaques were (2.43 ± 1.20) h and (6.26 ± 1.18) h, respectively, and the C max values were (40.05 ± 7.63) mg · L -1 And (29.23 ± 5.91) mg · L -1 and (408.22 ± 81.27) mg · h -1 and (413.21 ± 89.04) mg · h · L -1 for AUC_ (0-t) (-1). Domestic dogs in oral colitis positioning tablets after about 6.5h emodin in the colon more, and almost no detection of emodin in the small intestine. Conclusion: The colitis locating tablet achieves the goal of oral administration for oral administration in dogs.