研究了四环类药物与金属离子、生物大分子、有机小分子的相互作用，模拟体内环境研究了这些物质对药物的竞争作用，初步证明这些药物分子在体内存在的状态． The interactions between tetracyclines and metal ions, biological macromolecules and small organic molecules were studied. The competitive effects of these substances on drugs were simulated in vivo and the status of the existence of these drug molecules in vivo was initially proved.