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为分析2型糖尿病患者神经-内分泌-免疫网络紊乱情况及其临床意义,选择174例经临床诊断明确的2型糖尿病患者,用放射免疫法和流式细胞技术检测外周血中CD4+、CD8+、NK细胞数量、CD4+/CD8+比值及IL-1β、IL-6、TNF-α、ACTH、CORT、DA、NE水平,选择30例健康志愿者为正常对照组进行相同检测。结果显示,与正常对照相比,2型糖尿病患者CD4+、CD8+及NK细胞数量下降(P<0.01),CD8+及CD4+/CD8+比值升高(P<0.01),IL-1β、IL-6和TNF-α均有升高(P<0.01),ACTH及CORT下降(P<0.01),DA和NE升高(P<0.01)。研究表明,2型糖尿病患者神经-内分泌-免疫网络的紊乱中,其体液免疫增强、细胞免疫减弱,交感神经兴奋及应激性内分泌功能减弱为主要表现。对于2型糖尿病的治疗,除采用现有手段,应加强机体对胰岛素抵抗调控平衡态的修复与重建,重视神经-内分泌-免疫系统标志的检测及相应的新治疗研究。
In order to analyze the neuroendocrine-immune network disorder in patients with type 2 diabetes and its clinical significance, 174 clinically diagnosed type 2 diabetic patients were selected. The levels of CD4 +, CD8 +, NK in peripheral blood were measured by radioimmunoassay and flow cytometry 30 healthy volunteers were selected as normal control group for the same test, and the number of CD4 + / CD8 + cells and IL-1β, IL-6, TNF-α, ACTH, CORT, DA and NE were measured. The results showed that the numbers of CD4 +, CD8 + and NK cells in type 2 diabetic patients were decreased (P <0.01), the ratio of CD8 + and CD4 + / CD8 + was increased (P <0.01) (P <0.01), ACTH and CORT decreased (P <0.01), DA and NE increased (P <0.01). Studies have shown that in patients with type 2 diabetes, neuroendocrine-immune network disorders, enhanced humoral immunity, decreased cellular immunity, sympathetic nerve activation and stress-induced endocrine function as the main performance. For the treatment of type 2 diabetes, in addition to the existing means, should strengthen the body’s balance of insulin resistance regulation and repair and reconstruction, emphasis on neuroendocrine-immune system markers and the corresponding new treatment study.