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目的:分析口服西比灵胶囊联合静脉滴注川芎嗪注射液治疗椎-基底动脉供血不足性眩晕的疗效和安全性。方法:采用随机数字表法将96例椎-基底动脉供血不足性眩晕患者分为2组,对照组给予静脉滴注川芎嗪注射液治疗,观察组给予口服西比灵胶囊联合静脉滴注川芎嗪注射液治疗,均治疗7天为1疗程,2个疗程后比较临床疗效和药物安全性。结果:观察组总有效率93.75%,明显优于对照组77.08%,差异具有统计学意义(P<0.05);组间不良反应比较,差异无统计学意义(P>0.05)。结论:西比灵联合川芎嗪能够通过解除血管痉挛性收缩和改善脑组织脑血氧供应明显改善椎-基底动脉供血不足性眩晕患者的临床症状和体征,安全可靠,值得临床继续研究和推广。
Objective: To analyze the efficacy and safety of oral Xibiling capsules combined with intravenous infusion of ligustrazine in vertigo-basilar insufficiency vertigo. Methods: Ninety-six patients with vertebro-basilar artery insufficiency vertigo were divided into two groups by random number table method. The control group was given intravenous infusion of ligustrazine injection. The observation group was given oral xibiben capsule combined with intravenous infusion of ligustrazine Injection treatment, were treated for 7 days for a course of treatment, after 2 courses of clinical efficacy and drug safety. Results: The total effective rate in the observation group was 93.75%, which was significantly better than that in the control group (77.08%), the difference was statistically significant (P <0.05). There was no significant difference in the adverse reactions between the two groups (P> 0.05). Conclusion: Sibelium combined with ligustrazine can relieve vasospastic contraction and improve cerebral blood oxygen supply significantly improve the vertebrobasilar insufficiency vertigo patients with clinical symptoms and signs, safe and reliable, it is worth continuing clinical research and promotion.