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巨噬细胞(Mφ)在炎症反应、组织修复和防御反应中,可能释放生长因子作用于成纤维细胞、血管内皮细胞和平滑肌。近年来,有学者报道,Mφ所分泌的肿瘤坏死因子(TNF),具有很强的血管再生作用。TNF 在活化巨噬细胞血管再过生程中,可能起介质作用.TNF 是用结核杆菌致敏动物后第10～14天再给与细菌脂多糖时,由Mφ或单核细胞释放的活性物质。当把TNF 给与移植肿瘤的动物时,可引起肿瘤坏死。所以,TNF 作为抗肿瘤药物,通过基因工程能够大量获
Macrophages (Mφ) may release growth factors that act on fibroblasts, vascular endothelial cells and smooth muscle in inflammatory reactions, tissue repair and defense responses. In recent years, some scholars have reported that Mφ secretion of tumor necrosis factor (TNF), has a strong role in vascular regeneration. TNF may play a mediator role in revascularization of activated macrophages.TNF is an active substance released by Mφ or monocytes upon administration of bacterial lipopolysaccharide from day 10 to 14 after sensitization with M. tuberculosis . Tumor necrosis can be caused when TNF is given to a tumor-transplanted animal. Therefore, TNF as an antitumor drug can be obtained in large quantities by genetic engineering