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目的观察大黄素对癫痫大鼠的脑保护作用。方法120只大鼠分为对照组(n=24)、模型组(n=24)和给药组(n=72)。观察大黄素对大鼠脑含水量、脑皮层超氧化物歧化酶(SOD)活性、丙二醛(MDA)水平和脑皮层Na~+-K~+ATP酶的影响,并且比较三组大鼠的脑组织病理切片与电镜照片,观察其形态变化。结果大黄素可减轻脑水肿,升高SOD、Na~+-K~+ATP酶活性,降低MDA水平,影响多个病理生理通路,具有脑保护作用。结论大黄素可能是大黄发挥脑保护作用的有效成分之一,为临床治疗癫痫提供了一条新的途径。
Objective To observe the neuroprotective effect of emodin on epileptic rats. Methods 120 rats were divided into control group (n=24), model group (n=24) and administration group (n=72). To observe the effects of emodin on brain water content, activity of superoxide dismutase (SOD) in brain cortex, malondialdehyde (MDA) level, and Na~+-K~+ ATPase in brain cortex, and compare three groups of rats The histopathological sections and electron micrographs of the brain were observed for morphological changes. Results Emodin can relieve brain edema, increase SOD, Na~+-K~+ ATPase activity, decrease MDA level, affect multiple pathophysiological pathways, and have brain protection. Conclusion Emodin may be one of the effective components of the protective effect of rhubarb on the brain, which provides a new approach for clinical treatment of epilepsy.