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Fas(CD95 )及其配体 (FasL)属TNF和NGF受体家族。Fas在多种质细胞表面均有表达 ,Fas与FasL结合可引起多种细胞产生凋亡。近年来研究发现FasL在多种肿瘤细胞的表面和细胞质中表达 ,同时已证实肿瘤周围激活的淋巴细胞表面有Fas的表达 ,而这些淋巴细胞的凋亡异常增加。因此推测表达FsaL的肿瘤细胞能诱发淋巴细胞的异常凋亡或抑制其功能 ,肿瘤细胞表面表达的FasL可能在局部免疫抑制中起着重要的作用。另一方面 ,在肿瘤患者的外周血中发现肿瘤细胞分泌的可溶性FasL(sFasL) ,这些sFasL可能会诱发各类表达Fas的细胞凋亡 ,很多研究结果这一机制在肿瘤的生长、转移和肿瘤细胞逃避宿主免疫监视等方面亦可能发挥重要的作用。本文着重就上述现象及针对Fas FasL途径可能采取的免疫治疗策略作一综述
Fas (CD95) and its ligand (FasL) belong to the TNF and NGF receptor family. Fas is expressed on the surface of many kinds of cells, and the combination of Fas and FasL can cause apoptosis in many kinds of cells. In recent years, studies have found that FasL is expressed on the surface and cytoplasm of a variety of tumor cells, and it has been confirmed that Fas is expressed on the surface of activated lymphocytes around the tumor, and the apoptosis of these lymphocytes is abnormally increased. Therefore, it is speculated that tumor cells expressing FsaL can induce abnormal apoptosis of lymphocytes or inhibit their function. FasL expressed on the surface of tumor cells may play an important role in local immunosuppression. On the other hand, soluble FasL (sFasL) secreted by tumor cells is found in the peripheral blood of tumor patients. These sFasLs may induce apoptosis of various Fas-expressing cells. Many studies have found that this mechanism is involved in tumor growth, metastasis, and tumors. Cells may also play an important role in evading host immune surveillance. This article focuses on the above phenomenon and the possible immunotherapy strategies for the Fas FasL pathway.