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目的:探讨利用碲-锌-镉(CZT)SPECT行n 99Tcn m-甲氧基异丁基异腈(MIBI)/n 123I-间碘苄胍(MIBG)双核素显像的可行性。n 方法:利用A、B、C 3种心脏模型分别模拟正常心肌模型、n 99Tcn m/n 123I匹配心肌、n 99Tcn m/n 123I不匹配心肌，分别采集n 99Tcn m单核素和n 99Tcn m/n 123I双核素显像图像并进行比较；对2018年9月至2020年6月间阜外医院19例患者[男9例，女10例；年龄(56±16)岁]先后行n 99Tcn m-MIBI心肌灌注显像(MPI)和n 99Tcn m-MIBI心肌灌注/n 123I-MIBG心脏神经双核素显像，分别应用SPECT灌注定量(QPS)软件计算所有心肌节段的灌注百分比(PP%)和左心室整体心肌的灌注总评分(SRS)，对单核素和双核素显像方法进行比较和相关分析(Pearson相关和Spearman秩相关)。心脏模型和患者图像均不进行物理校正。采用重复测量方差分析和Mann-Whitney n U检验分析数据。n 结果:心脏模型中，n 99Tcn m单核素和n 99Tcn m/n 123I双核素图像差别很小，n 123I对n 123I-MIBG n 99Tcn m图像无明显影响。19例患者n 99Tcn m-MIBI单核素显像和n 99Tcn m-MIBI/n 123I-MIBG双核素显像的心肌节段PP%分别为(69.2±14.5)%和(69.5±16.2)%(n F＝0.005，n P＝0.946)，两者具有较高的相关性(n r＝0.845，n P<0.01)。2种显像方法的SRS分别为2(1，13)和2(2，12)(n z＝-0.774，n P＝0.439)，也具有较高的相关性(n rs＝0.975，n P<0.01)。n 结论:即使不行物理校正，较高能量的n 123I对n 99Tcn m图像的干扰对心脏图像判读也没有明显影响，心脏n 99Tcn m-MIBI/n 123I-MIBG双核素显像可行。n “,”Objective:To study the feasibility of cardiac n 99Tcn m-methoxyisobutylisonitrile (MIBI)/ n 123I-metaiodobenzylguanidine (MIBG) dual-isotope imaging with cadmium-zinc-telluride (CZT) SPECT.n Methods:Using a heart phantom, n 99Tcn m-MIBI single-isotope imaging and n 99Tcn m-MIBI/n 123I-MIBG dual-isotope imaging were acquired separately. Model A, B, C represented normal heart, n 99Tcn m/n 123I matched myocardium, n 99Tcn m/n 123I mismatched myocardium, respectively. Nineteen patients (9 males, 10 females; age (56±16) years) from September 2018 to June 2020 at Fuwai Hospital were enrolled to participate n 99Tcn m-MIBI myocardial perfusion imaging and myocardial perfusion/cardiac sympathetic imaging with n 99Tcn m-MIBI/n 123I-MIBG dual-isotope. Perfusion percent (PP%) and summed rest score (SRS) for all myocardial segments were obtained using quantitative perfusion SPECT (QPS) software by analyzing myocardial perfusion images. Difference and relationship between PP% and SRS were analyzed (Pearson and Spearman correlation analyses). No physical correction was applied for both acquisitions. Analysis of variance for repeated measurement data and Mann-Whitney n U test were used.n Results:There was no significant difference in myocardial perfusion images between n 99Tcn m single-isotope and n 99Tcn m/n 123I dual-isotope imaging with the heart phantom. n 123I did not significantly impact on n 99Tcn m images. For patients, PP% did not differ between n 99Tcn m single-isotope ((69.2±14.5)%) and n 99Tcn m/n 123I dual-isotope imaging ((69.5±16.2)%; n F=0.005, n P=0.946) and correlated well (n r=0.845, n P<0.01). SRS forn 99Tcn m single-isotope was 2(1, 13) and 2(2, 12) for n 99Tcn m/n 123I dual-isotope imaging (n z=-0.774, n P=0.439) and the correlation between the two acquisitions was excellent (n rs=0.975, n P<0.01).n Conclusions:Even without physical correction, cardiac images interpretation won′t be significantly influenced by the interference of n 123I with relatively higher energy on n 99Tcn m images. Cardiac n 99Tcn m-MIBI/n 123I-MIBG dual-isotope imaging is feasible.n