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本文系用人体全血培养方法,比较研究了由MMC诱导的淋巴细胞微核率和人体外周血细胞中SOD活性及MDA浓度变化之间的关系,结果显示微核率、MDA浓度与MMC剂量（0～2.99×10~（-4）mmol/L）之间呈正相关,而SOD活性与MMC剂量呈负相关;微核率与MDA浓度呈正相关,而与SOD活性呈负相关;SOD活性与MDA浓度之间呈负相关,故认为自由基在微核形成过程中起重要的作用。
In this study, the relationship between micronucleus rate induced by MMC and SOD activity in peripheral blood cells and MDA concentration in human was studied by using human whole blood culture method. The results showed that micronucleus rate, MDA concentration and MMC dose (0 ~ 2.99 × 10 ~ (-4) mmol / L), while the activity of SOD was negatively correlated with the dosage of MMC. The micronucleus rate was positively correlated with the concentration of MDA and negatively correlated with the activity of SOD. The activity of SOD and the concentration of MDA Was negatively correlated, so that free radicals play an important role in the formation of micronuclei.