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目的:观察化湿行瘀清热方剂联合重组人干扰素α-2b(r IFN-α2b)溶液口腔涂压治疗口腔扁平苔藓(OLP)的疗效。方法:将160例OLP患者随机分为观察组与对照组,各80例。两组均予以常规对症治疗,观察组予以化湿行瘀清热方剂联合r IFN-α2b口腔涂压治疗,比较两组的近期、中远期疗效及免疫炎症指标。结果:观察组近期、中远期总有效率分别为93.75%、88.75%,显著高于对照组的82.50%、77.50%(P<0.05);两组治疗后临床评分均显著提高,且观察组显著高于对照组(P<0.05);两组治疗后IL-6、IL-8、TNF-α、VEGF及CD_8~+均显著降低,且观察组显著低于对照组(P<0.05);两组CD_3~+、CD_4~+、CD_4~+/CD_8~+均较治疗前显著上升,且观察组显著高于对照组(P<0.05);观察组6个月及12个月复发率均显著低于对照组(P<0.05)。结论:化湿行瘀清热方剂联合r IFN-α2b口腔涂压治疗OLP疗效显著,可调节患者的免疫功能,促进病情康复,值得在临床中推广应用。
OBJECTIVE: To observe the curative effect of oral administration of Huayu line stasis-heat prescription combined with recombinant human interferon α-2b (r IFN-α2b) solution on oral lichen planus (OLP). Methods: 160 OLP patients were randomly divided into observation group and control group, 80 cases each. The two groups were given conventional symptomatic treatment, the observation group were treated with Huayu line stasis heat recipe combined with r IFN-α2b oral pressure treatment, the two groups of short-term, long-term efficacy and immune inflammation indicators. Results: The total effective rate of the observation group was 93.75% and 88.75%, respectively, which was significantly higher than that of the control group (82.50% and 77.50%, P <0.05). The clinical scores of the observation group and the observation group (P <0.05). The levels of IL-6, IL-8, TNF-α, VEGF and CD_8 in the two groups were significantly lower than those in the control group (P <0.05) The levels of CD_3 ~ +, CD_4 ~ +, CD_4 ~ + / CD_8 ~ + in the two groups were significantly higher than those before treatment, and the observation group was significantly higher than the control group (P <0.05) Significantly lower than the control group (P <0.05). Conclusion: The treatment of OLP with Huayu line stasis clearing heat prescription combined with r IFN-α2b oral pressure has significant curative effect, which can adjust the immune function of patients and promote the recovery of the disease, so it is worth popularizing and applying in clinic.