论文部分内容阅读
目的:探讨CD133蛋白和p53蛋白在结直肠腺瘤组织中的表达及其临床病理学意义。方法:运用免疫组化PV9000二步法检测CD133及p53在172例结直肠腺瘤及正常黏膜组织中的表达。结果:结直肠腺瘤CD133和p53的阳性率分别为40.7%和21.5%。CD133和p53的表达均与肿瘤的大小、病变程度及肿瘤组织学分型有关,P值均<0.05。CD133和p53在结直肠腺瘤中的表达呈正相关,r=0.344,P<0.05。CD133及p53在腺瘤组织中表达明显高于正常黏膜组织,P<0.05。结论:CD133及p53在结直肠腺瘤的发生发展中起着重要作用,可能成为临床新的辅助诊断和监测预后的指标。
Objective: To investigate the expression of CD133 protein and p53 protein in colorectal adenoma and its clinicopathological significance. Methods: The expression of CD133 and p53 in 172 cases of colorectal adenoma and normal mucosa was detected by immunohistochemistry PV9000 two-step method. Results: The positive rates of CD133 and p53 in colorectal adenomas were 40.7% and 21.5%, respectively. The expression of CD133 and p53 were related to the size of the tumor, the degree of the lesion and the histological type of the tumor, all P <0.05. There was a positive correlation between the expression of CD133 and p53 in colorectal adenoma (r = 0.344, P <0.05). The expression of CD133 and p53 in adenoma was significantly higher than that in normal mucosa (P <0.05). Conclusion: CD133 and p53 play an important role in the development of colorectal adenoma and may be a new index of clinical diagnosis and prognosis.