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氟哌啶醇,化学名4-[4-基-4-(4-氯苯)-4-羟基派啶]-4’-氟丁酰苯,是一种重要的抗精神病药。该药物的测定主要采用紫外光度法,其他尚有气相和薄层色谱法,荧光法等。但灵敏度都不够高,难以用于微量和痕量分析,特别是病人体液中含量的监测。 Bishop等发现,氟哌啶醇在金和铂电极上既不还原也不氧化,认为这种药物在上述电极上不具有电活性。本文发现氟哌啶醇能吸附于玻碳电极,并发生氧化反应。据此拟定了吸附伏安法测定该药物的方案,并研究了药物在玻碳表面的吸附行为。
Haloperidol, the chemical name 4- [4-yl-4- (4-chlorophenyl) -4-hydroxypyridine] -4’- fluorobutyryl benzene, is an important antipsychotics. The determination of the drug using UV spectrophotometry, there are other gas phase and thin layer chromatography, fluorescence and so on. But the sensitivity is not high enough, it is difficult to trace and trace analysis, especially the monitoring of the patient’s body fluid content. Bishop et al. Found that haloperidol neither reduced nor oxidized on the gold and platinum electrodes and that the drug is not electrically active on the electrodes described above. This paper found that haloperidol can be adsorbed on the glassy carbon electrode, and the oxidation reaction. Based on this, a scheme of measuring the drug by voltammetry was developed and the adsorption behavior of the drug on the glassy carbon surface was studied.