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结核病是由Mtb引起的一种呼吸道传染病,全球结核病疫情仍然十分严峻,而卡介苗预防结核病的效果并不理想,研究新型结核病疫苗已成为国内外结核病研究的热点之一。将本课题组自1998年至今研究MtbAg85ADNA疫苗的免疫原性、治疗效果进行综合与概述,结果表明Mtb Ag85ADNA疫苗可诱导小鼠体液免疫和Th1型细胞免疫应答,可减少小鼠组织中的Mtb尤其是耐多药Mtb的数目,该疫苗与常规化疗联合不仅可提高机体免疫力,并可有效地杀灭或抑制Mtb,从而提高化疗效果。
Tuberculosis is a kind of respiratory disease caused by Mtb. The global epidemic of tuberculosis is still very serious. The effect of BCG in preventing tuberculosis is not ideal. To study the new tuberculosis vaccine has become one of the hot spots in tuberculosis research at home and abroad. The research group from 1998 to now study the immunogenicity of MtbAg85ADNA vaccine and treatment effect summary and summary of the results showed that Mtb Ag85ADNA vaccine can induce humoral and Th1-type immune response in mice can reduce the mouse tissue Mtb in particular Is the number of multidrug-resistant Mtb that, in combination with conventional chemotherapy, not only enhances the body’s immunity but also effectively kills or inhibits Mtb, thereby increasing the efficacy of chemotherapy.