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目的 :探讨正常足月妊娠和妊高征胎盘内皮型一氧化氮合酶 (NOS3 )的分布及其对胎儿胎盘循环的影响。方法 :收集正常足月妊娠胎盘 10只 ,妊高征足月胎盘 16只 (轻度 6只 ,中重度 10只 ) ,采用间接免疫荧光组织化学法分析NOS3 的分布及其含量。结果 :正常足月妊娠和妊高征胎盘NOS3 的分布范围无明显差异 ,但后者荧光强度减弱 ,轻度与中重度之间无差别。结论 :足月妊娠胎盘NOS3 的分布以滋养层和脐血管内皮为主 ,其含量的降低可能与参与妊高征的发病过程有关
Objective: To investigate the distribution of endothelial nitric oxide synthase (NOS3) and its effect on fetal placental circulation in normal term pregnancy and pregnancy induced hypertension. Methods: Ten normal pregnant women with placenta of pregnancy and 16 full-term placenta of pregnancy induced hypertension (mild and moderate severe 10) were collected. The distribution and content of NOS3 were analyzed by indirect immunofluorescence histochemistry. Results: There was no significant difference in the distribution of NOS3 in normal term pregnancy and pregnancy induced hypertension placenta, but the latter had weaker fluorescence intensity and no difference between mild and moderate severe. Conclusion: The distribution of NOS3 in placenta of full-term pregnancy is dominated by trophoblast and umbilical vascular endothelium. The decrease of its content may be related to the pathogenesis of PIH