以四氯化碳CCl_4 2.5mg/kg灌大鼠胃可导致其肝钙含量明显升高,同时伴有明显肝细胞损伤。在灌四氯化碳前1h和灌四氯化碳后6h各注射阿托品、东莨菪碱和山莨菪碱1次,可明显减轻肝钙积累(P>0.05)并伴有明显的组织学改善。提示大剂量莨菪类药物对肝细胞损伤具有一定的保护作用,这对抗中毒性休克可能有一定意义。 Perfusion of rat stomach with carbon tetrachloride CCl_4 2.5 mg/kg resulted in a significant increase in hepatic calcium content, accompanied by significant hepatocyte injury. Atropine, scopolamine and anisodamine were injected once 1 h before carbon tetrachloride and 6 h after carbon tetrachloride injection, which can significantly reduce liver calcium accumulation (P>0.05) with obvious histological improvement. It is suggested that high-dose steroids have a protective effect on hepatocyte injury, which may have some significance against toxic shock.