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基质金属蛋白酶9(MMP9)是一种基质金属蛋白酶,脑缺血时可以通过降解基底膜及紧密连接破坏血脑屏障,从而导致脑缺血后继发性脑水肿和脑出血。了解MMP9及其与脑缺血性损伤的关系、脑缺血时其在中枢神经系统的变化、及其在脑缺血时如何作用于血脑屏障,无疑为预防和治疗脑缺血后的并发症指出了新的方向。
Matrix metalloproteinase 9 (MMP9) is a matrix metalloproteinase, which can damage the blood-brain barrier by degrading the basement membrane and tight junctions during cerebral ischemia, resulting in secondary cerebral edema and cerebral hemorrhage after cerebral ischemia. To understand the relationship between MMP9 and cerebral ischemic injury, its changes in the central nervous system during cerebral ischemia, and how it acts on the blood-brain barrier during cerebral ischemia undoubtedly for the prevention and treatment of post-ischemic complications Disease pointed out a new direction.