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目的探讨小剂量肝素在治疗妊娠期高血压疾病重度子痫前期中的作用。方法选取妊娠期高血压疾病重度子痫前期患者40例,随机分为两组,对照组20例采用传统解痉降压等治疗方法,实验组20例在传统治疗基础上加用小剂量肝素治疗,比较两组患者治疗前后血压控制、尿蛋白下降、血液浓缩改善情况及产后出血、新生儿病理性黄疸发生率。结果实验组血压控制明显优于对照组,尿蛋白较对照组无显著减少,红细胞压积下降及尿量增加较对照组明显,且不增加产后出血与新生儿病理性黄疸的发生率。结论在传统方法上加用小剂量肝素治疗妊娠期高血压疾病重度子痫前期安全有效,值得推广。
Objective To investigate the role of low-dose heparin in the treatment of severe preeclampsia of gestational hypertension. Methods Forty patients with severe preeclampsia of gestational hypertension were randomly divided into two groups. 20 cases in the control group were treated by traditional antispasmodic and antihypertensive treatment. 20 cases in the experimental group were treated with low-dose heparin on the basis of traditional treatment The blood pressure, urinary protein, blood concentration, postpartum hemorrhage and the incidence of neonatal pathological jaundice were compared between the two groups before and after treatment. Results The blood pressure in the experimental group was significantly better than that in the control group. The urinary protein was not significantly reduced compared with the control group. The decrease of hematocrit and the increase of urine volume were more obvious than the control group. The incidence of postpartum hemorrhage and neonatal pathological jaundice was not increased. Conclusions It is safe and effective to add small dose of heparin to the traditional method to treat gestational hypertension with severe preeclampsia and it is worth to be popularized.