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目的观察喜炎平注射液对轮状病毒性肠炎(RVE)患儿心肌的保护作用,并探讨其相关的作用机制及临床疗效。方法选取2014年4月至2016年1月我院收治的RVE患儿142例,采用随机数字表法分为2组,各71例。对照组给予常规抗病毒治疗,治疗组在对照组治疗方法的基础上加喜炎平注射液治疗。治疗结束后使用ELISA法测定乳酸脱氢酶(LDH)、肌酸激酶(CK)、肌酸激酶同工酶(CK-MB)、白细胞介素-17(IL-17)、白细胞介素-6(IL-6)和肿瘤坏死因子-α(TNF-α)的含量,比较2组治疗后的总有效率和不良反应发生率。结果治疗组和对照组临床总有效率分别为94.4%和81.7%,治疗组显著高于对照组,差异有统计意义(P<0.05)。2组治疗前LDH,CK,CK-MB,IL-17,IL-6和TNF-α含量差异均无统计意义(P>0.05);与同组治疗前比较,2组治疗后LDH,CK,CK-MB,IL-17,IL-6和TNF-α含量均显著降低(P<0.05或P<0.01);治疗后,治疗组LDH,CK,CK-MB,IL-17,IL-6和TNF-α含量降低程度均显著高于对照组(P<0.05)。2组不良反应发生率比较,差异无统计意义(P>0.05)。结论喜炎平注射液治疗RVE患儿临床疗效显著,不仅可以抑制炎症反应,而且能保护患儿心肌。
Objective To observe the protective effect of Xiyanping Injection on myocardium in children with rotavirus enteritis (RVE) and to explore its related mechanism of action and clinical efficacy. Methods 142 patients with RVE admitted to our hospital from April 2014 to January 2016 were randomly divided into 2 groups (n = 71). The control group was given conventional antiviral therapy, and the treatment group was treated with Xiyanping Injection on the basis of the control group. After treatment, the levels of lactate dehydrogenase (LDH), creatine kinase (CK), creatine kinase (CK-MB), interleukin-17 (IL-17), interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) in the two groups were compared. The total effective rate and incidence of adverse reactions in the two groups were compared. Results The total clinical effective rates in the treatment group and the control group were 94.4% and 81.7%, respectively, which were significantly higher in the treatment group than those in the control group (P <0.05). The levels of LDH, CK, CK-MB, IL-17, IL-6 and TNF-α in the two groups had no significant difference before treatment (P> 0.05) The levels of CK-MB, IL-17, IL-6 and TNF-α were significantly decreased (P <0.05 or P <0.01) TNF-α levels were significantly lower than the control group (P <0.05). The incidence of adverse reactions in the two groups, the difference was not statistically significant (P> 0.05). Conclusion Xiyanping injection in children with RVE significant clinical efficacy, not only can inhibit the inflammatory response, but also to protect children with myocardial.