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目的对中国人载脂蛋白B基因XbaI酶切位点限制性片段长度多态性与脑梗死关系进行Me-ta分析。方法通过文献检索收集相关病例对照研究,对纳入文献进行异质性检验及合并分析。结果纳入11篇文献合并统计,总体效应检验未发现统计学上的差异(Z=1.72,P=0.08);分组分析发现北方人群XbaI多态性位点在X-X+/X+X+基因型水平与脑梗死发病有统计学意义(OR=2.66,95%CI:1.67～4.24);南方人群在此基因型水平无统计学差异(OR=1.26,95%CI:0.90～1.77)。结论Meta分析提示载脂蛋白B基因XbaI多态性位点可能增加中国北方人群脑梗死风险,对南方人群的影响尚不确定。
Objective To analyze the relationship between the restriction fragment length polymorphism of XbaI restriction site of Chinese apolipoprotein B gene and cerebral infarction. Methods The related case-control study was collected through literature search, and the heterogeneity test and combined analysis of the included literature were conducted. Results There was no significant difference in the overall effect test (Z = 1.72, P = 0.08) among the 11 articles. The group analysis found that the XbaI polymorphism loci of northern population were at the genotype X-X + / X + X + (OR = 2.66,95% CI: 1.67 ~ 4.24). There was no significant difference in the genotype between the southern population (OR = 1.26, 95% CI: 0.90-1.77). Conclusions Meta-analysis suggests that XbaI polymorphism of apolipoprotein B gene may increase the risk of cerebral infarction in northern Chinese population, but the effect on southern population is uncertain.